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Naukowcy z Massachusetts General Hospital (MGH) wykazali, że wbrew temu, co pisze się w podręcznikach, narządem, w którym eliminowane są uszkodzone bądź naturalne postarzałe erytrocyty, nie jest śledziona, ale wątroba. Zachodzi w niej również recykling żelaza. Wg Amerykanów, nowo zdobyta wiedza może m.in. poprawić leczenie lub zapobieganie anemii.„Podręczniki mówią nam, że czerwone krwinki są eliminowane przez wyspecjalizowane makrofagi ze śledziony, ale nasze badanie pokazuje, że to wątroba, a nie śledziona stanowi główne miejsce usuwania erytrocytów i recyklingu żelaza. […] Zidentyfikowaliśmy [też] przejściową populację komórek szpikopochodnych do spraw recyklingu” – opowiada Filip Swirski.
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.[...]AbstractIron is an essential component of the erythrocyte protein hemoglobin and is crucial to oxygen transport in vertebrates. In the steady state, erythrocyte production is in equilibrium with erythrocyte removal. In various pathophysiological conditions, however, erythrocyte life span is compromised severely, which threatens the organism with anemia and iron toxicity. Here we identify an on-demand mechanism that clears erythrocytes and recycles iron. We show that monocytes that express high levels of lymphocyte antigen 6 complex, locus C1 (LY6C1, also known as Ly-6C) ingest stressed and senescent erythrocytes, accumulate in the liver via coordinated chemotactic cues, and differentiate into ferroportin 1 (FPN1, encoded by SLC40A1)-expressing macrophages that can deliver iron to hepatocytes.
Mass. General study reveals how the body disposes of red blood cells, recycles ironAccumulation and removal of aged or damaged cells found to take place mostly in the liver, rather than the spleenWhat happens when red blood cells become damaged or reach the end of their normal life span, and how is the iron required for carrying oxygen recycled? A new study led by Massachusetts General Hospital (MGH) investigators contradicts previous thinking about where and how worn-out red blood cells are disposed of and their iron retained for use in new cells. Their findings, being published online in Nature Medicine, may lead to improved treatment or prevention of anemia or iron toxicity.
